Endocrine Abstracts

Hypertension is the most commonly recognised cardiac manifestation of a phaeochromocytoma. There are however a variety of other cardiac presentations including arrhythmias and the increasingly reported Takotsubo cardiomyopathy. We present the case of a female patient presenting acutely to the general medical take who was found to have cardiac arrhythmias and transient left ventricular dysfunction.The initial presentation was breathlessness, chest pain, s...

Introduction: Thyrotoxicosis of iatrogenic origin is well recognized, particularly with use of drugs such as amiodarone and lithium. However, thyrotoxicosis after parathyroid surgery is rarely reported and has been poorly characterized within prospective studies. We report the case of a lady who underwent parathyroidectomy who developed self-limiting thyrotoxicosis.Case: A 42 year old lady presented with recurrent urinary tract infections due to bilatera...

Introduction: Pituitary apoplexy is an uncommon medical emergency with a reported incidence in pituitary adenomas of 2–7%. UK guidelines on the management of pituitary apoplexy have recently been published. On this background we analysed the management of pituitary apoplexy at a single tertiary centre.Methods: A retrospective analysis was performed to evaluate clinical presentation, management and clinical outcomes in a cohort of patients, who prese...

Temporary hypocalcaemia following total thyroidectomy occurs in around 30% of patients and is usually due to inadvertent damage to the parathyroid glands. Whilst mild cases are easily managed with oral calcium supplementation, there is the potential for severe calcium deficit with the ensuing risks of cardiac dysrhythmias, tetany and in extreme cases death. It is common practice to have a post-surgery protocol to allow the early identification of these patients. Whilst many pr...

A 59-year-old lady was admitted with lethargy and dehydration in October 1998 and investigations confirmed primary hyperparathyroidism with corrected calcium 4.49 mmol/l (N: 2.1–2.6). After fluid resuscitation, she underwent parathyroidectomy and biopsy revealed parathyroid hyperplasia. Post-operatively, her calcium remained normal until November 2000 when her corrected calcium was 3.05 mmol/l with PTH 311 ng/l (N: 12–65). Sestamibi scan failed to local...

Background: Surgery, sometimes supported by adjunctive radiotherapy (RT), is the treatment of choice for patients with non-functioning pituitary adenoma (NFA). Previous studies have shown that patients treated with pituitary RT have doubling of mortality ratio due to cerebrovascular disease (CVD) but the reason for this excess is unclear. Transcranial Doppler (TCD) can be used to measure blood velocity in the middle cerebral arteries (MCAs) within the circle of Willis and also...

A 69-year-old man with no family history of thyroid disease presented with weight gain and constipation. He was clinically euthyroid with no goitre. Investigations confirmed autoimmune hypothyroidism with FT4 16.9 pmol/l (N: 10–22), TSH 29.14 mIU/l (N: 0.4–4.5), elevated thyroid peroxidase (TPO) antibodies 3311 IU/ml (N: 0–34) and he was commenced on thyroxine with serial dose adjustments to 250 mcg OD over 2 years. His TSH however remained ...

In response to the 2003 Government White Paper entitled ‘Our future, Our inheritance’, we piloted a project to promote the genetic service within tertiary medicine. Three clinical nurse specialists (CNS); renal, cardiac and endocrine, are the catalyst for interaction between disciplines. This abstract relates the endocrine genetic experience.Targeting patients and families with genetic endocrine disease is achieved by three methods; identificat...

Background: Surgery, sometimes supported by adjunctive radiotherapy (RT) are the treatments of choice for patients with non-functioning pituitary adenomas (NFA). Previous studies have implicated these treatments in deficits of cognitive function, particularly memory and executive functioning, although this research has often been confounded by the inclusion of patients with hormone producing tumours. The aim of this study was to determine the impact of RT on psychometric funct...

Aim: The main aim of this study was to evaluate the prevalence of kidney stones and osteoporosis in a cohort of patients with a confirmed diagnosis of primary hyperparathyroidism (PHPT).Study design: This retrospective study reviewed the clinical records of patients with a confirmed diagnosis of PHPT in a single tertiary referral centre for metabolic bone disease over a period of 6 years (January 2010 – December 2015).Patients...